Trimester Pregnancy Care
Your Pregnancy - Our Priority
Fertility Testing Services
Providers of Comprehensive Care
At Trimester, we see our patients as a part of the family—and family is always our top priority. Scroll down to read more about our services.
Genetic Fertilty Screening
Easy, Reliable and Complete
About 10-15% of male infertility cases and 8-10% of female infertility cases are associated with genetic alterations, which can include chromosomal abnormalities or single gene mutations. 20% of the cases is defined as “idiopathic infertility” because it is not possible with certainty, to diagnose the presence of underlying causes.
Data from the Medically Assisted Procreation National Register. Italian National Institute of Health. “Infertility and PMA techniques.”
Fertiscan
A further study by the Italian National Institute of Health indicates that infertility involves 15% of couples and equally affects males and females.
INFERTILITY
A study by the Italian National Institute of Health indicates that infertility involves 15% of couples and equally affects men and women. About 10-15% of male infertility cases and 8-10% of female infertility cases are associated with genetic alterations, which can include chromosomal abnormalities or single gene mutations. 20% of the cases is defined as “idiopathic infertility” because it is not possible to diagnose with certainty the presence of underlying causes.
FertiScan™ is an innovative genetic test for the evaluation of the infertility genetic causes.
There are two lines of investigation:
FertiScan™ Female Infertility Panel
FertiScan™ Male Infertility Panel
GLOBAL FEMALE INFERTILITY PANEL
Female infertility panel is a test for the evaluation of women’s reproductive health, designed to identify female infertility most common genetic causes and the rarest genetic abnormalities associated with infertility and recurrent miscarriage.
The test includes simultaneous analysis of more than 70 genes for the study of female infertility main causes, including Primary Ovarian Insufficiency, Ovarian dysfunction, Ovarian dysgenesis, Embryonic lethality, Recurrent miscarriage and Oocyte maturation defects.
FertiScan™ Female:
Female Fertiscan tests are available in a targeted version for the investigation of specific disorders associated with an increased risk of infertility in women, and in a complete version through the Global Female Infertility Panel.
• Fertiscan ™ Global Female Infertility Panel 70 genes
• Fertiscan ™ - Primary Ovarian Insufficiency/Ovarian Dysfunction NGS Panel 50 genes
• FertiScan ™ - Ovarian Dysgenesis NGS panel 11 genes
• FertiScan ™ - Preimplantation embryonic lethality NGS Panel 3 genes
• FertiScan ™ - Oocyte maturation defect NGS panel 5 genes
• Fertiscan ™ - Miscarriage NGS panel 14 genes
• Fertiscan ™ - Polycystic Ovary Syndrome 2 genes
• Fertiscan ™ - Ovarian Hyperstimulation Syndrome / Ovarian response to Ovarian stimulation 5 genes
GLOBAL MALE INFERTILITY PANEL
Male infertility panel is a test for the evaluation of men’s reproductive health, designed to identify male infertility most common genetic causes.
The test includes simultaneous analysis of more than 50 genes for the study of male infertility main causes, including Azoospermia, Asthenospermia and abnormal sperm morphology.
FertiScan ™ Male:
FertiScan ™ Global Male Infertility Panel 50 genes
Indication To FertiScan ™:
• Conditions of recurrent miscarriage
• Couples with reproductive difficulties
• Multiple attempts at artificial insemination
• Couples who are approaching assisted reproductive technology pathways
• Family history of hereditary infertility conditions
High-Resolution Sequencing Technology
The genes included in the FertiScan™ panels* are entirely sequenced at high reading depth thanks to the use of Next Generation Sequencing (NGS) technologies. The analysis involves the complete study of the coding portion of each gene (full exon sequencing) at high resolution.
How The Test Works:
1. SAMPLE COLLECTION
2. DNA EXTRACTION
3. DNA SEQUENCING Next Generation Sequencing (NGS)
4. IDENTIFICATION OF DNA MUTATIONS
5. RESULTS
The genetic sequences obtained are interpreted by an advanced bioinformatic analysis, in order to identify any mutations associated with pathologies in the analyzed genes.
